Yayınlar
2025
Tecik M., Adan A. Concurrent inhibition of FLT3 and sphingosine kinase-1 triggers synergistic cytotoxicity in midostaurin resistant FLT3-ITD positive acute myeloid leukemia cells via blocking FLT3/STAT5A signaling to induce apoptosis. J Chemother. 202. pp.1-17. doi:10.1080/1120009X.2025.2478340.
2024
Sarı S, Özsoy ER. Aurora Kinases: Their Role in Cancer and Cellular Processes. TJNS. June 2024;13(2):128-139. doi:10.46810/tdfd.1476374.
Adan A. DNA Methylation Alterations in Acute Myeloid Leukemia: Therapeutic Potential. In: Hematological Cancer Diagnosis and Treatment: An Interdisciplinary Approach. Springer, Cham. 2024. ISBN: 978-3-031-75448-7. doi:10.1007/16833_2023_192.
Uçar Akyürek T, Orhan IE, Şenol Deniz FS, Eren G, Acar B, Sen A. Evaluation of Selected Plant Phenolics via Beta-Secretase-1 Inhibition, Molecular Docking, and Gene Expression Related to Alzheimer’s Disease. Pharmaceuticals. 2024; 17(11):1441. doi.org/10.3390/ph17111441.
Yilmaz A, Koca M, Ercan S, Acar OO, Boga M, Sen A, Kurt A. Amelioration potential of synthetic oxime chemical cores against multiple sclerosis and Alzheimer's diseases: Evaluation in aspects of in silico and in vitro experiments. J. Mol. Struct. Volume 1318, Part 1, 15 December 2024, 139193. doi.org/10.1016/j.molstruc.2024.139193.
Gencer Akçok EB, Güner H, Akçok İ. Determination of promising inhibitors for N-SH2 domain of SHP2 tyrosine phosphatase: an in silico study. Mol Divers. 2024 May 13. doi: 10.1007/s11030-024-10880-2.
Ayvaz HB, Yenigül M, Gencer Akçok EB. Tomatidine, a Steroidal Alkaloid, Synergizes with Cisplatin to Inhibit Cell Viability and Induce Cell Death Selectively on FLT3-ITD+ Acute Myeloid Leukemia Cells. Cell Biochem Biophys. 2024 Jul 11. doi: 10.1007/s12013-024-01406-6.
Pir MS, Begar E, Yenisert F, Demirci HC, Korkmaz ME, Karaman A, Tsiropoulou S, Firat-Karalar EN, Blacque OE, Oner SS, Doluca O, Cevik S, Kaplan OI. CilioGenics: an integrated method and database for predicting novel ciliary genes. Nucleic Acids Res. Published online July 11, 2024. doi:10.1093/nar/gkae554.
Bicer M. Revolutionizing dermatology: harnessing mesenchymal stem/stromal cells and exosomes in 3D platform for skin regeneration. Arch Dermatol Res. 2024;316(6):242. Published 2024 May 25. doi:10.1007/s00403-024-03055-4.
Tecik M, Adan A. Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors. Curr. Treat. Options in Oncol. 2024. https://doi.org/10.1007/s11864-024-01202-7.
Şansaçar M, Sağır H, Gencer Akçok EB. Inhibition of PI3K-AKT-mTOR pathway and modulation of histone deacetylase enzymes reduce the growth of acute myeloid leukemia cells. Med Oncol. 2024. https://doi.org/10.1007/s12032-023-02247-8.
Şansaçar M, Gencer Akçok EB. Measurement of Autophagic Activity in Cancer Cells with Flow Cytometric Analysis Using Cyto-ID Staining. Methods Mol Biol. 7 Mart 2024. https://doi.org/10.1007/7651_2024_526.
Fidan O, Mujwar S In silico Evaluation of the Potential of Natural Products from Chili Pepper as Antiviral Agents Against Dna-Directed Rna Polymerase of the Monkeypox Virus. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. 2024; 13(1): 277 - 291. 10.17798/bitlisfen.1388403.
2023
Bay ÖF, Hayes KS, Schwartz, JM, Grencis RK, Roberts IS. A genome-scale metabolic model of parasitic whipworm. Nat Commun. 2023;14(1):6937. https://doi.org/10.1038/s41467-023-42552-4.
Gunalp S, Helvaci DG, Oner A, Bursalı A, Conforte A, Güner H, Karakülah G, Szegezdi E, Sag D. TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content. Front Immunol. 2023;21;14:1209249. doi: 10.3389/fimmu.2023.1209249.
Cevik S, Peng X, Beyer T, Pir MS, Yenisert F, Woerz F, Hoffmann F, Altunkaynak B, Pir B, Boldt K, Karaman A, Cakiroglu M, Oner SS, Cao Y, Ueffing M, Kaplan OI. WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium. Life Sci Alliance. 2023;19;6(8):e202201844. doi: 10.26508/lsa.202201844.
Cevik S, Zhao P, Zorluer A, Pir MS, Bian W, Kaplan OI. Matching variants for functional characterization of genetic variants. G3 (Bethesda). 2023;jkad227. doi: 10.1093/g3journal/jkad227.
Turan MG, Orhan ME, Cevik S, Kaplan OI. CiliaMiner: an integrated database for ciliopathy genes and ciliopathies. Database (Oxford). 2023;26;2023:baad047. doi: 10.1093/database/baad047.
Yenigül M, Gencer Akcok EB. Histone Deacetylase Inhibition and Autophagy Modulation Induces a Synergistic Antiproliferative Effect and Cell Death in Cholangiocarcinoma Cells. ACS Omega. 2023;8(24):21755-21768. doi:10.1021/acsomega.3c01317.
Senol, H, Celik-Turgut G, Sen A, Saglamtas R, Tuncay S, Gulcin I, Topcu G. Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors. Med Chem Res. 2023. doi:10.1007/s00044-023-03031-z.
Celik-Turgut G, Olmez N, Koc T, Ozgun-Acar O, Semiz A, Dodurga Y, Lale Satiroglu-Tufan N, Sen A. Role of AHR, NF-kB and CYP1A1 crosstalk with the X protein of Hepatitis B virus in hepatocellular carcinoma cells. Gene. 2023;853:147099. doi:10.1016/j.gene.2022.147099.
Senol H, Ozgun-Acar O, Dağ A, Eken A, Guner H, Aykut ZG, Topcu G, Sen A. Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent. J Nat Prod. 2023;86(1):103-118. doi:10.1021/acs.jnatprod.2c00798.
2022
Erdogan Orhan I, Deniz FSS, Salmas RE, Irmak S, Acar OO, Turgut GC, Sen A, Zbancioc AM, Luca SV, Skiba A, Skalicka-Woźniak K, Tataringa G. Evaluation of Anti-Alzheimer Activity of Synthetic Coumarins by Combination of in Vitro and in Silico Approaches. Chem Biodivers. 2022;19(12):e202200315. doi:10.1002/cbdv.202200315.
Ozgun-Acar O, Celik-Turgut G, Guner H, Sezer S, Sen A. Biochemical, pharmacological, and toxicological attributes of caper (Capparis ovata) flowering buds and berries pickles. Food Sci Nutr. 2022;10(12):4189-4200. Published 2022 Jul 30. doi:10.1002/fsn3.3012.
Acar MB, Ayaz-Guner S, Guner H, Dinc G, Ulu Kılıc A, Doganay M, Ozcan S. A subtractive proteomics approach for the identification of immunodominant Acinetobacter baumannii vaccine candidate proteins. Front Immunol. 2022;13:1001633. Published 2022 Nov 10. doi:10.3389/fimmu.2022.1001633.
Sulak M, Turgut GC, Sen A. Cerium Oxide Nanoparticles Biosynthesized Using Fresh Green Walnut Shell in Microwave Environment and their Anticancer Effect on Breast Cancer Cells. Chem Biodivers. 2022;19(8):e202200131. doi:10.1002/cbdv.202200131.
Sen A. Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes. Turk J Med Sci. 2022;52(5):1425-1447. doi:10.55730/1300-0144.5482.
Pir MS, Cevik S, Kaplan OI. ConVarT: Search Engine for Missense Variants Between Humans and Other Organisms. Curr Protoc. 2022;2(11):e619. doi:10.1002/cpz1.619.
Pir MS, Bilgin HI, Sayici A, Coşkun F, Torun FM, Zhao P, Kang Y, Cevik S, Kaplan OI. ConVarT: a search engine for matching human genetic variants with variants from non-human species. Nucleic Acids Res. 2022;50(D1):D1172-D1178. doi:10.1093/nar/gkab939.
Turan MG, Kantarci H, Temtek SD, Cakici O, Cevik S, Kaplan OI. Protocol for determining the average speed and frequency of kinesin and dynein-driven intraflagellar transport (IFT) in C. elegans. STAR Protoc. 2022;3(3):101498. doi:10.1016/j.xpro.2022.101498.
Cicek E, Kucuktas FM, Yenigul M, Gencer Akcok EB. Cytotoxic and cytostatic effects of targeting mTOR and Hedgehog pathways in acute myeloid leukemia. Experimed. 2022. doi: 10.26650/experimed.1193721.
Sansacar M, Sagir H, Gencer Akcok EB. AML-240: Investigation of the Antitumor Effect of Targeting PI3K-AKT-mTOR Pathway and Histone Deacetylase Enzymes on Acute Myeloid Leukemia Cells. Clin Lymphoma Myeloma Leuk. 2022. doi:10.1016/S2152-2650(21)01702-X.
Tecik M, Adan A. Therapeutic Targeting of FLT3 in Acute Myeloid Leukemia: Current Status and Novel Approaches. Onco Targets Ther. 2022. doi:10.2147/OTT.S384293.
Yenigül M, Akçok İ, Gencer Akçok EB. Ethacrynic acid and cinnamic acid combination exhibits selective anticancer effects on K562 chronic myeloid leukemia cells. Mol Biol Rep. 2022. doi:10.1007/s11033-022-07560-5.
Ersöz NŞ, Adan A. Differential in vitro anti-leukemic activity of resveratrol combined with serine palmitoyltransferase inhibitor myriocin in FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) carrying AML cells. Cytotechnology. 2022. doi.org/10.1007/s10616-022-00527-1.
Sahin HN, Adan A. Combined effect of midostaurin and sphingosine kinase-1 inhibitor on FMS-like tyrosine kinase 3 (FLT3) wild type acute myeloid leukemia cells. Turkish J. Biochem. 2022. doi.org/10.1515/tjb-2021-0152.
Ersöz NŞ, Adan A. Resveratrol triggers anti-proliferative and apoptotic effects in FLT3-ITD-positive acute myeloid leukemia cells via inhibiting ceramide catabolism enzymes. Med. Oncol. 2022;39(35):1-13. doi.org/10.1007/s12032-021-01627-2.
2021
Yenigül M, Gencer Akcok EB. The therapeutic potential of targeting HDAC6 with Tubastatin A in TFK-1 and EGI-1 cholangiocarcinoma cells. Cumhuriyet Sci. J. 2021;42(4):775-780. doi.org/10.17776/csj.963107.
Kavakcioglu Yardimci B, Ozgun-Acar O, Semiz A, Sen A. Apatinib Sensitizes Human Breast Cancer Cells against Navitoclax and Venetoclax Despite Up-regulated Bcl-2 and Mcl-1 Gene Expressions. Turkish Journal of Oncology.2021;36(1):8-16. doi:10.5505/tjo.2020.2380.
Hitit M, Özbek M, Ayaz-Guner S, Guner H, Oztug M, Bodu M, Kirbas M, Bulbul B, Bucak MN, Ataman MB, Memili E, Kaya A. Proteomic fertility markers in ram sperm. Anim Reprod Sci. 2021;235:106882. doi:10.1016/j.anireprosci.2021.106882.
Şahin HN, Adan A. Glucosylceramide Synthase Is a Novel Biomarker of Midostaurin-Induced Cytotoxicity in Non-Mutant FLT3 Positive Acute Myeloid Leukemia Cells. Experimed. 2021;11(3):149-55. doi: 10.26650/experimed.2021.974943.
Oğuz O, Adan A. Involvement of Sphingolipid Metabolism Enzymes in Resveratrol-Mediated Cytotoxicity in Philadelphia-Positive Acute Lymphoblastic Leukemia. Nutr Cancer. 2021;1-14. doi: 10.1080/01635581.2021.2005806.
Acar MB, Ayaz-Guner S, Gunaydin Z, Karakukcu M, Peluso G, Di Bernardo G, Ozcan S, Galderisi U. Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells. Frontiers in Bioengineering and Biotechnology. 2021;9;10.3389/fbioe.2021.730813. doi: 10.3389/fbioe.2021.730813.
Cevik S, Kaplan OI. The Joubert syndrome protein CEP41 is excluded from the distal segment of cilia in C. elegans. MicroPubl Biol. 2021;2021:10.17912/micropub.biology.000406. doi: 10.17912/micropub.biology.000406.
Cevik S, Kaplan OI. Subcellular localization of the voltage-gated K+ channel EGL-36 , a member of the KV3 subfamily, in the ciliated sensory neurons in C. elegans. MicroPubl Biol. 2021;2021:10.17912/micropub.biology.000367. doi: 10.17912/micropub.biology.000367.
Acar MB, Aprile D, Ayaz-Guner S, Guner H, Tez C, Di Bernardo G, Peluso G, Ozcan S, Galderisi U. Why Do Muse Stem Cells Present an Enduring Stress Capacity? Hints from a Comparative Proteome Analysis. International Journal of Molecular Sciences. 2021; 22(4):2064. doi: 10.3390/ijms22042064.
Gürdap, S., Bayram, N. N., İşoğlu, I. A., & Dinçer İşoğlu, S.. Sulfobetaine-Based Homo-and Copolymers by RAFT: Cross-Linked Micelles and Aqueous Solution Properties. ACS Applied Polymer Materials, 4(9), 6303-6311. (2022)
2020
Ersöz NŞ, Adan A. Cytotoxic Effects of Resveratrol and Its Combinations with Ceramide Metabolism Inhibitors on FLT3 Positive Acute Myeloid Leukemia. Erzincan University Journal of Science and Technology. 2020;13(3):1205-1216. doi: 10.18185/erzifbed.764085.
Acar MB, Ayaz-Güner S, Di Bernardo G, Güner H, Murat A, Peluso G, Özcan S, Galderisi U. Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue. Aging (Albany NY). 2020;12:10.18632/aging.202423. doi: 10.18632/aging.202423.
Gazioglu I, Semen S, Acar OO, Kolak U, Sen A, Topcu G. Triterpenoids and steroids isolated from Anatolian Capparis ovata and their activity on the expression of inflammatory cytokines. Pharm Biol. 2020;58(1):925-931. doi: 10.1080/13880209.2020.1814356.
Semiz, A., Ozgun Acar, O., Cetin, H., Semiz, G., & Sen, A. Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis. Journal of Translational Internal Medicine. 2020;8(3):177-187. doi: 10.2478/jtim-2020-0027.
Ercan A. Sex effect on the correlation of immunoglobulin G glycosylation with rheumatoid arthritis disease activity. Turk J Biol. 2020;44(6):406-416. doi: 10.3906/biy-2005-7.
Sen A. Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases. World J Clin Cases. 2020;8(10):1767-1792. doi: 10.12998/wjcc.v8.i10.1767.
Ayaz-Guner S, Alessio N, Acar MB, et al. A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions. Cell Commun Signal. 2020;18(1):118. doi: 10.1186/s12964-020-00614-w.
Saçar Demirci MD, Adan A. Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection. PeerJ. 2020;8:e9369. doi: 10.7717/peerj.9369.
Akşit, N. N., Gürdap, S., İşoğlu, S. D., & İşoğlu, İ. A. Preparation of antibacterial electrospun poly (D, L-lactide-co-glycolide)/gelatin blend membranes containing Hypericum capitatum var. capitatum. International Journal of Polymeric Materials and Polymeric Biomaterials 1-13 (2020).
İşoğlu, İ.A., Koç, N. Centella Asiatica Extract Containing Bilayered Electrospun Wound Dressing. Fibers and Polymers 22 (2020).
Srivastava, K., Fidan, O., Shi, YM., Tang, N., Liu, C., Song, Y., Nowak-Wegryzn, A., Haque, N., Zhan, J. & Li, X-M. Berberine-containing Natural Medicine Confers Sustained Peanut Tolerance Associated with Distinct Microbiota Signature. Journal of Allergy and Clinical Immunology 145, AB84 (2020).
Asif, M., Zora, S., Ceylan, Y., Rehman, R., & Ozturk, L.. Nitrogen supply in combination of nitrate and ammonium enhances harnessing of elevated atmospheric CO2 through improved nitrogen and carbon metabolism in wheat (Triticum aestivum). Crop and Pasture Science, 71(2), 101-112. (2020)
Tarhan, S. Z., Koçer, A. T., Özçimen, D., & Gökalp, İ. Utilization of hydrothermal process water for microalgae growth. Eurasian Journal of Biological and Chemical Sciences, 3(1), 42-47. (2020)
Uslu F, Icoz K, Tasdemir K, Doğan R.S, Yilmaz B. Image-analysis based readout method for biochip: Automated quantification of immunomagnetic beads, micropads and patient leukemia cell. Micron. (2020)
Gökçe B., Akçok İ., Çağır A., Peşen-Okvur D.. A new drug testing platform based on 3D tri-culture in lab-on-a-chip devices. European Journal of Pharmaceutical Sciences, 155, 105542. (2020)
2019
Brown KA, Chen B, Guardado-Alvarez TM, Lin Z, Ayaz-Guner S, Jin S, Ge Y. A photocleavable surfactant for top-down proteomics. Nat Methods. 2019;16(5):417-420. doi: 10.1038/s41592-019-0391-1.
Sen A, Stark H. Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis. World J Gastroenterol. 2019;25(23):2846-2862. doi: 10.3748/wjg.v25.i23.2846.
Sen A, Ayar B, Yılmaz A, Acar Ö, Turgut G, Topçu G. Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption. Turk J Chem. 2019; 43(5): 1350-1364.
Ege T, Ozkan AMG, Sen A, Adali O. Evaluation of in vivo effects of Viscum album l. and its constituent o-coumaric acid on bile acid synthesizing CYPs. FEB. 2019;28(4): 2825-2834.
Delman M, Avcı ST, Akçok İ, Kanbur T, Erdal E, Çağır A., Antiproliferative activity of (R)-4’-methyllavuzon on heptacellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition. European Journal of Medicinal Chemistry, 180, 224-237 (2019).
Yürük, A., İşoğlu İ.A. 3-Sulfopropyl methacrylate based cryogens as potential tissue engineering scaffolds. Materials Technology, 1-10 (2019).
Bal, B., Tugluca, I. B., Koc, N., & Isoglu, I. A. On the detailed mechanical response investigation of PHBV/PCL and PHBV/PLGA electrospun mats. Materials Research Express 6(6) 065411 (2019).
İşoğlu, İ. A., Bölgen, N., Korkusuz, P., Vargel, İ., Çelik, H. H., Kılıç, E., ... & Pişkin, E. Stem cells combined 3D electrospun nanofibrous and macrochannelled matrices: a preliminary approach in repair of rat cranial bones. Artificial cells, nanomedicine, and biotechnology 47(1), 1094-1100 (2019).
Kadayifci, M. S., Gokkaya, D., Topuzogullari, M., Isoglu, S. D., Atabey, T., Arasoglu, T., & Ozmen, M. M. Core‐crosslinking as a pathway to develop inherently antibacterial polymeric micelles. Journal of Applied Polymer Science, 48393 (2019).
Kaplan OI, Torun FM, Guner H, Cevik S, Conserved clinical variation visualization tool (ConVarT), The European Journal of Human Genetics, 27, 1697-1698 (2019)
Fidan, O., Yan, R., Zhu, D. & Zhan, J. Improved production of antifungal angucycline Sch47554 by manipulating three regulatory genes in Streptomyces sp. SCC‐2136. Biotechnology and applied biochemistry 66, 517-526 (2019).
Fidan, O. & Zhan, J. Discovery and engineering of an endophytic Pseudomonas strain from Taxus chinensis for efficient production of zeaxanthin diglucoside. Journal of biological engineering 13, 66 (2019).
Yuan, H., Wang, H., Fidan, O., Qin, Y., Xiao, G. & Zhan, J. Identification of new glutamate decarboxylases from Streptomyces for efficient production of γ-aminobutyric acid in engineered Escherichia coli. Journal of Biological Engineering 13, 24 (2019).